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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 5
2004 7
2005 1
2006 4
2007 7
2008 4
2009 8
2010 9
2011 8
2012 7
2013 9
2014 11
2015 8
2016 18
2017 13
2018 21
2019 19
2020 14
2021 16
2022 19
2023 11
2024 7

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193 results

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Page 1
Endoplasmic Reticulum Stress and the Hallmarks of Cancer.
Urra H, Dufey E, Avril T, Chevet E, Hetz C. Urra H, et al. Trends Cancer. 2016 May;2(5):252-262. doi: 10.1016/j.trecan.2016.03.007. Epub 2016 Apr 23. Trends Cancer. 2016. PMID: 28741511 Review.
Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation.
Wheeler MA, Jaronen M, Covacu R, Zandee SEJ, Scalisi G, Rothhammer V, Tjon EC, Chao CC, Kenison JE, Blain M, Rao VTS, Hewson P, Barroso A, Gutiérrez-Vázquez C, Prat A, Antel JP, Hauser R, Quintana FJ. Wheeler MA, et al. Cell. 2019 Jan 24;176(3):581-596.e18. doi: 10.1016/j.cell.2018.12.012. Epub 2019 Jan 17. Cell. 2019. PMID: 30661753 Free PMC article.
Genome-wide studies have identified genetic variants linked to neurologic diseases. Environmental factors also play important roles, but no methods are available for their comprehensive investigation. ...We found that the herbicide linuron amplifies astrocyte pro-inflammat …
Genome-wide studies have identified genetic variants linked to neurologic diseases. Environmental factors also play important roles, …
Identification of astrocyte regulators by nucleic acid cytometry.
Clark IC, Wheeler MA, Lee HG, Li Z, Sanmarco LM, Thaploo S, Polonio CM, Shin SW, Scalisi G, Henry AR, Rone JM, Giovannoni F, Charabati M, Akl CF, Aleman DM, Zandee SEJ, Prat A, Douek DC, Boritz EA, Quintana FJ, Abate AR. Clark IC, et al. Nature. 2023 Feb;614(7947):326-333. doi: 10.1038/s41586-022-05613-0. Epub 2023 Jan 4. Nature. 2023. PMID: 36599367 Free PMC article.
We applied FIND-seq to study the regulation of astrocytes characterized by the splicing-driven activation of the transcription factor XBP1, which promotes disease pathology in multiple sclerosis and experimental autoimmune encephalomyelitis(4). Using FIND-seq in combinatio …
We applied FIND-seq to study the regulation of astrocytes characterized by the splicing-driven activation of the transcription factor XBP …
Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging.
Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y, Hung MD, Vidal R, Fuentealba M, Miedema T, Duran-Aniotz C, Diaz J, Ibaceta-Gonzalez C, Sabusap CM, Bermedo-Garcia F, Mujica P, Adamson S, Vitangcol K, Huerta H, Zhang X, Nakamura T, Sardi SP, Lipton SA, Kennedy BK, Henriquez JP, Cárdenas JC, Plate L, Palacios AG, Hetz C. Cabral-Miranda F, et al. EMBO J. 2022 Nov 17;41(22):e111952. doi: 10.15252/embj.2022111952. Epub 2022 Oct 31. EMBO J. 2022. PMID: 36314651 Free PMC article.
Proteomic profiling of hippocampal tissue showed that XBP1 expression significantly restore changes associated with aging, including factors involved in synaptic function and pathways linked to neurodegenerative diseases. The genes modified by XBP1 in the age …
Proteomic profiling of hippocampal tissue showed that XBP1 expression significantly restore changes associated with aging, including …
Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology.
El Manaa W, Duplan E, Goiran T, Lauritzen I, Vaillant Beuchot L, Lacas-Gervais S, Morais VA, You H, Qi L, Salazar M, Ozcan U, Chami M, Checler F, Alves da Costa C. El Manaa W, et al. Autophagy. 2021 Dec;17(12):4363-4385. doi: 10.1080/15548627.2021.1917129. Epub 2021 May 24. Autophagy. 2021. PMID: 34030589 Free PMC article.
The mechanisms underlying these perturbations and how they are directly linked remain a matter of questions. XBP1 is a transcription factor activated upon ER stress after unconventional splicing by the nuclease ERN1/IREalpha thereby yielding XBP1s, whereas PINK1 is a kinas …
The mechanisms underlying these perturbations and how they are directly linked remain a matter of questions. XBP1 is a transcription …
Brain injury triggers cell-type-specific and time-dependent endoplasmic reticulum stress responses.
Fan Q, Takarada-Iemata M, Okitani N, Tamatani T, Ishii H, Hattori T, Kiryu-Seo S, Kiyama H, Hori O. Fan Q, et al. Glia. 2023 Mar;71(3):667-681. doi: 10.1002/glia.24303. Epub 2022 Nov 22. Glia. 2023. PMID: 36412235
Despite accumulating evidence suggesting that the UPR plays a role in neurodegenerative diseases and brain insults, our understanding of how ER stress is induced under neuropathological conditions is limited. ...GFP signals were observed in injured neurons early (fr …
Despite accumulating evidence suggesting that the UPR plays a role in neurodegenerative diseases and brain insults, our unders …
Endoplasmic reticulum: a primary target in various acute disorders and degenerative diseases of the brain.
Paschen W. Paschen W. Cell Calcium. 2003 Oct-Nov;34(4-5):365-83. doi: 10.1016/s0143-4160(03)00139-8. Cell Calcium. 2003. PMID: 12909082 Review.
IRE1, on the other hand, is turned after activation into an endonuclease that cuts out a sequence of 26 bases from the coding region of xbp1 mRNA. Processed xbp1 mRNA is translated into the respective protein, an active transcription factor specific for ER stress ge …
IRE1, on the other hand, is turned after activation into an endonuclease that cuts out a sequence of 26 bases from the coding region of x …
Metformin ameliorates brain damage caused by cardiopulmonary resuscitation via targeting endoplasmic reticulum stress-related proteins GRP78 and XBP1.
Chuan L, Huang X, Fan C, Wen S, Yang X, Wang J, Ren J, Ru J, Ding L. Chuan L, et al. Eur J Pharmacol. 2021 Jan 15;891:173716. doi: 10.1016/j.ejphar.2020.173716. Epub 2020 Nov 13. Eur J Pharmacol. 2021. PMID: 33197442
This study aimed to explore the role of metformin in protecting brain endoplasmic reticulum post CA/CPR. Male SD rats (n = 132) were treated with 6-min CA-posted asphyxia and sham surgery. ...Furthermore, metformin inhibited the mRNA and protein expressions of glucose-regu …
This study aimed to explore the role of metformin in protecting brain endoplasmic reticulum post CA/CPR. Male SD rats (n = 132) were …
Compound Tongluo Decoction inhibits endoplasmic reticulum stress-induced ferroptosis and promoted angiogenesis by activating the Sonic Hedgehog pathway in cerebral infarction.
Hui Z, Wang S, Li J, Wang J, Zhang Z. Hui Z, et al. J Ethnopharmacol. 2022 Jan 30;283:114634. doi: 10.1016/j.jep.2021.114634. Epub 2021 Sep 16. J Ethnopharmacol. 2022. PMID: 34536518
ETHNOPHARMACOLOGICAL RELEVANCE: Cerebral infarction is one of the most common types of cerebrovascular diseases that threaten people's health. Compound Tongluo Decoction (CTLD), a traditional Chinese medicine formula, has various pharmacological activities, including the a …
ETHNOPHARMACOLOGICAL RELEVANCE: Cerebral infarction is one of the most common types of cerebrovascular diseases that threaten people' …
The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis.
Duran-Aniotz C, Poblete N, Rivera-Krstulovic C, Ardiles ÁO, Díaz-Hung ML, Tamburini G, Sabusap CMP, Gerakis Y, Cabral-Miranda F, Diaz J, Fuentealba M, Arriagada D, Muñoz E, Espinoza S, Martinez G, Quiroz G, Sardi P, Medinas DB, Contreras D, Piña R, Lourenco MV, Ribeiro FC, Ferreira ST, Rozas C, Morales B, Plate L, Gonzalez-Billault C, Palacios AG, Hetz C. Duran-Aniotz C, et al. Mol Ther. 2023 Jul 5;31(7):2240-2256. doi: 10.1016/j.ymthe.2023.03.028. Epub 2023 Apr 4. Mol Ther. 2023. PMID: 37016577
Inositol-requiring enzyme-1 (IRE1) operates as a central ER stress sensor, enabling the establishment of adaptive and repair programs through the control of the expression of the transcription factor X-box binding protein 1 (XBP1). To artificially enforce the adaptive capa …
Inositol-requiring enzyme-1 (IRE1) operates as a central ER stress sensor, enabling the establishment of adaptive and repair programs throug …
193 results